Post-Doctoral Associate

The Gale Laboratory at University of Minnesota aims to define the molecular mechanisms of innate immune activation and viral regulation of innate immunity, and to define therapeutic targets to inform research and development toward building innate immune therapeutics to combat virus infection. The laboratory studies cell culture, mouse models, nonhuman primate models, and human cohorts of virus infection and immunity. The lab works within specialized resources and administrative framework for performing cellular and animal BSL2, BSL3, BSL4 studies of a range of RNA viruses including flaviviruses, Hanta virus, influenza A viruses, SARS-CoV-2 and other coronaviruses, Ebola virus, chikungunya virus, SIV, and HIV. The lab also conducts functional genomics studies using high-throughput RNA sequencing (RNAseq) including ATCseq, CITEseq, bulk mRNAseq, and GeoMx spatial-seq approaches to define virus/host interactions, host genes of virus control, and therapeutic targets for infection control strategies.

Primary Duties
70% Research Primary duties and responsibilities will include, but are not limited to, studies of virus-host interactions using virus infection model systems. The project involves basic research and outbreak response isolating virus from primary specimens, developing and evaluating infection models, and leveraging animal models and human studies in systems biology approaches. The project applies functional genomics analyses of virus infection models with an overall goal to understand the mechanisms of innate immune activation and response for control of virus infection. The work also focused on understanding how the innate immune response programs the adaptive immune response to direct effective gene expression and humoral and cellular immune responses. The successful candidate will work in BSL2, BSL2+ , and BSL3 environments, and will build and use viral vectors, expression constructs, and will prepare RNA-based therapeutics and vaccines, test small molecules, and assess vaccines in various model systems. The work also involves interaction with other lab member(s), participation in lab meetings, and overseeing the work of undergraduate students.

30% of the position includes data analysis, presentations, and manuscript preparation for reporting of experimental results. The successful candidate will use different computer programs and statistical tests to analyze the immune response in animals. Analysis of flow cytometry results will be done using FlowJo or Cyflogic programs and involves analysis of fluorescence readouts, live/dead cells discrimination and multi color compensation; analysis of functional genomics data sets will utilize a variety of computational applications.

Required Qualifications:

• A Ph.D. (or equivalent) degree in virology, microbiology, cell biology, immunology or a related field - Advanced knowledge in molecular, cellular biology, and virology techniques.
• Experience in immunological methods such as ELISA, antibody characterization, and western blot; proficiency in PCR amplification, cloning, protein expression and purification, and tissue culture techniques.
• Excellent written and verbal communication and organization skills with proficient scientific record keepingAbility to work independently, pay attention to details, solve problems, work under pressure and manage multiple tasks
• Experience and ability to analyze scientific data, present the research results and prepare manuscripts for publication

Preferred Qualifications:

• Experience in work with bacteria, human cells/tissues and viruses in a BL2+/BSL3 facility
• Previous work with HIV-1/SIV, flaviviruses, alphaviruses, influenza A virus, and/or SARS-CoV-2 assays.
• Bioinformatics experience
• Experience with writing and following an institutional animal care and use committee (IACUC) and human subjects protocols

The Department of Microbiology and Immunology is committed to discovering and disseminating knowledge about the microbial world. Our interests and expertise encompass some of the most exciting areas of contemporary microbiology, ranging from the physiology and development of microorganisms to the molecular pathogenesis of infections.

Working at the University

At the University of Minnesota, you'll find a flexible work environment and supportive colleagues who are interested in lifelong learning. We prioritize work-life balance, allowing you to invest in the future of your career and in your life outside of work.

The University also offers a comprehensive benefits package that includes:

• Competitive wages, paid holidays, and generous time off
• Continuous learning opportunities through professional training and degree-seeking programs supported by the Regents Tuition Benefit Program
• Low-cost medical, dental, and pharmacy plans
• Healthcare and dependent care flexible spending accounts
• University HSA contributions
• Employee wellbeing program
• Public Service Loan Forgiveness (PSLF) opportunity
• Financial counseling services
• Employee Assistance Program with eight sessions of counseling at no cost

Please visit the Office of Human Resources website for more information regarding benefits.

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-8647.

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu

Any offer of employment is contingent upon the successful completion of a background check. Our presumption is that prospective employees are eligible to work here. Criminal convictions do not automatically disqualify finalists from employment.

The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.

At the University of Minnesota, we are proud to be recognized by the Star Tribune as a Top Workplace for 2021, as well as by Forbes as Best Employers for Women and one of America's Best Employers (2015, 2018, 2019, 2023), Best Employer for Diversity (2019, 2020), Best Employer for New Grads (2018, 2019), and Best Employer by State (2019, 2022).