Scientist IIBrisbane, CA

CareDx, Inc. is a leading precision medicine solutions company focused on the discovery, development, and commercialization of clinically differentiated, high-value healthcare solutions for transplant patients and caregivers. CareDx offers products, testing services, and digital healthcare solutions along the pre- and post-transplant patient journey, and is the leading provider of genomics-based information for transplant patients.

We are seeking a motivated and innovative Senior Scientist to join our dynamic R&D team. In this role, you will contribute to the development of cutting-edge diagnostic solutions, leveraging your expertise to drive assay development and validation projects. Collaboration is key, as you will interface with cross-functional teams, including bioinformatics, biostatistics and data science, clinical operations, software, automation, project management, manufacturing, regulatory and QA. Proficiency in molecular biology methods for nucleic acid characterization and related applications is essential, along with a critical and creative approach to problem-solving.

Responsibilities:

• Evaluate and optimize materials and processes within the Chemistry R&D team using HPLC, PCR and sequencing methods
• Initiate, design, and execute experiments to develop and/or improve high-value novel technology for development of diagnostic tests
• Serve as an internal team expert in cell biology including live/dead cells, primary blood cells, renal epithelial cells, extracellular vesicles, and FFPE tissue samples
• Evaluate novel sample prep and preservation methods in whole blood and urine samples.
• Develop DNA and RNA extraction techniques from different types of cells such as T-cells, B-cells, monocyte/macrophage and EVs
• Use molecular biology approaches to independently develop and optimize assays for chemistry technology development
• Perform HPLC analysis of nucleosides, nucleotides and oligonucleotides
• Provide expert support and guidance regarding experiment design, data analysis, and results to the broader scientific teams. Participate in troubleshooting
• Participate in drafting invention disclosures and SOPs for production and testing methods with knowledge input in QC/QA requirements
• Participate in design, initiation, and execution of experiments with the development team to enhance and automate high-value diagnostic tests

Qualifications:

• BS or MS in bioengineering or biomedical fields with deep practical knowledge of molecular biology with significant industrial experience (8-12 years) supported by strong publications/patent applications record. Technology development experience in Life Sciences and implementation of new methods and materials into operations is preferred
• Solid foundation in molecular biology, with hands-on experience in NGS library preparation and Illumina sequencing platforms. Familiarity with targeted RNASeq for differential gene expression using NGS is a plus
• Strong practical knowledge of handling blood samples and products including PBMC isolation, primary human blood cell magnetic sorting and analysis, fluorescence microscopy experience
• Experience with common chemistry analytical techniques HPLC, FPLC, Flow Cytometry, good general knowledge of chemistry and safe handling of chemicals
• Expertise in nucleic acid and plasma cell-free DNA extraction techniques including practical skills in lab automation such as liquid handling instruments
• Strong interdisciplinary communication skills to foster collaboration and effective knowledge exchange
• Excellent organizational skills with acute attention to detail, ensuring high-quality outputs in a fast-paced environment

Additional Details:

Every individual at CareDx has a direct impact on our collective mission to improve the lives of organ transplant patients worldwide. We believe in taking great care of our people, so they take even greater care of our patients.

Our competitive Total Rewards package for US Employees includes:

• Competitive base salary and incentive compensation
• Health and welfare benefits, including a gym reimbursement program
• 401(k) savings plan match
• Employee Stock Purchase Plan
• Pre-tax commuter benefits
• And more!
• Please refer to our page to view detailed benefits athttps://caredx.com/company/careers

In addition, we have a Living Donor Employee Recovery Policy that allows up to 30 days of paid leave annually to a full-time employee who makes the selfless act of donating an organ or bone marrow.

With products that are making a difference in the lives of transplant patients today and a promising pipeline for the future, it's an exciting time to be part of the CareDx team. Join us in partnering with transplant patients to transform our future together.

CareDx, Inc. is an Equal Opportunity Employer-vets/disabled, and participates in the E-Verify program.

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