New

Incident Response Engineer II

Quanterix
tuition assistance, 401(k)
United States, Massachusetts, Billerica
Jan 22, 2026
Incident Response Engineer II Billerica, MA Hybrid Quanterix is a global leader in ultra-sensitive biomarker detection, enabling breakthroughs in disease research, diagnostics, and drug development. Its proprietary Simoa technology delivers industry-leading sensitivity, allowing researchers to detect and quantify biomarkers in blood and other fluids at concentrations far below traditional limits. With more than 3,400 peer-reviewed publications, Quanterix has been a trusted partner to the scientific community for nearly two decades. In 2025, Quanterix acquired Akoya Biosciences, The Spatial Biology Company, adding multiplexed tissue imaging with single-cell resolution to its portfolio. Together, the combined company offers a uniquely integrated platform that connects biology across blood and tissue-advancing precision medicine from discovery to diagnostics. ROLE SUMMARY: Seeking a qualified Security Incident Response Engineer to join our growing organization and Information Security team. In this role you will work within the Security Operations team, reporting to the Director, IT Infrastructure and Security Operations. You will respond to security events, conduct analysis of threats such as malware and intrusion attempts, and provide security services to safeguard highly sensitive data. You will work hands-on with detection systems and vulnerability analysis tools to respond to potential threats to Quanterix systems. You should be prepared to relentlessly resolve security issues by gathering and analyzing event data and conducting root-cause analysis. With your technical expertise, you will be solving security challenges at scale, working to protect the applications that support Quanterix and our fast-growing business. We value broad and deep technical knowledge, specifically in the fields of forensics, malware analysis, network security, application security, threat hunting, and threat intelligence. WHAT YOU'LL DO: As a SME, you will be responsible for leading incidents, investigations, and security initiatives Act as a security multiplier to help scale security incident response at Quanterix Prepare post-mortem reports of incidents and present findings to the broader team Create and maintain runbooks to ensure smooth handling of all security incidents Lead and participate in incident response tabletop exercises to validate and improve existing processes and procedures and train others on their roles and responsibilities during an incident Monitor and analyze security logs, using KQL queries in Microsoft Sentinel, to identify potential security breaches Build, refine, and maintain analytic rules, workbooks, hunting queries, and dashboards in Microsoft Sentinel to enhance detection and response capabilities Automate incident response and enrichment processes using Logic Apps, automation rules, and playbooks in Sentinel Assess vulnerabilities within the environment, conduct risk-based prioritization of vulnerabilities, and assist in remediation Lead and coordinate responses to cyber threats, including incidents identified in Microsoft Defender for Endpoint Build effective relationships with key stakeholders who own and support IT infrastructure, applications, processes, and operations Provide security engineering solutions and support during customer-facing incidents, proactively considering prevention of similar incidents in the future Assist in the development of pragmatic solutions that meet business requirements while maintaining an acceptable level of risk Identify and recommend solutions that improve or expand Quanterix incident response capabilities Work alongside Information Security and Infrastructure Operations engineers to improve security, reduce risk, and rapidly address incidents Evaluate the impact of current security trends, advisories, publications, and academic research to Quanterix, coordinating responses as necessary across affected teams Stay current with the rapidly changing threat landscape, continuously improving detection and response methods Participate in an on-call rotation Other duties as needed BASIC QUALIFICATIONS: Bachelor's in computer science, information security, or equivalent professional experience 5+ years of demonstrated experience in areas such as incident response, systems security, network, and/or application security Billerica, MA Hybrid PREFERRED QUALIFICATIONS: Microsoft and Network administration coursework and/or certifications are preferred Knowledge of TCP/IP network Hands-on working experience with Microsoft Cloud Security, O365, Sentinel, Azure AD, Azure Identities and governance, Identity and Access Management, Microsoft Azure Sentinel, Azure Information Protect, Cloud App Security, MS Defender, Microsoft Cloud App Security and Endpoint Security Relevant industry certifications from SANS, ISC2, Microsoft Security, or similar EXPECTATIONS, COMPETENCIES, SKILLS & ABILITIES: Expertise with Microsoft Sentinel (SIEM/SOAR) including advanced KQL query writing, rule creation, and custom dashboards Hands-on experience with Microsoft Defender for Endpoint for endpoint detection and response. Proficiency in incident automation, including design and implementation of Logic Apps playbooks for triage, enrichment, and response Experience with vulnerability management solutions, SIEM solutions, and endpoint technologies such as CrowdStrike and other industry-leading tools Understanding of best practices in security engineering, including secure development, network security, security operations, systems security, and incident response Technical depth in one or more specialties including: application security, infrastructure security, digital forensics, malware analysis, threat hunting, or some combination thereof Strong understanding of security vulnerabilities, attacker exploit techniques, and methods for their remediation Experience with common security monitoring, log analysis, and forensic tools Ability to work with a high degree of autonomy Scripting skills (e.g., KQL, Python, PowerShell, Bash, etc.) for automation and integration of security tools Dedicated and passionate about cybersecurity technologies, constantly learning and evolving with current hacking techniques, cybercrime tactics, and industry trends Strong interpersonal and communication skills for coordinating responses to sophisticated incidents across the organization with both technical and non-technical stakeholders Technical security background and understanding of network fundamentals and common Internet protocols Experience triaging and developing security alerts, building automation pipelines, conducting front-line analysis, and providing escalation support Employee may be required to lift and/or move objects up to 50 pounds Night or weekend work as needed Occasional travel (<5%) to remote locations WHY YOU'LL LIKE WORKING WITH US: Our Technology: From discovery to diagnostics, Quanterix's ultrasensitive biomarker detection is fueling breakthroughs only made possible through its unparalleled sensitivity and flexibility. Simoa technology has delivered the gold standard for earlier biomarker detection in blood, serum or plasma, with the ability to quantify proteins that are far lower than the Level of Quantification (LoQ). Our industry-leading precision instruments, digital immunoassay technology and CLIA-certified Accelerator laboratory have supported research that advances disease understanding and management in neurology, oncology, immunology, cardiology, and infectious disease. Akoya Biosciences, a Quanterix company, is The Spatial Biology Company-bringing tissue context to life through high-resolution, single-cell imaging. Akoya's spatial phenotyping platforms help researchers visualize and measure how cells organize and interact within tissue to influence disease progression and therapeutic response. From discovery through clinical research, Akoya offers a full continuum of solutions, including PhenoCycler, PhenoImager Fusion and HT, and PhenoCode Panels. As part of Quanterix, Akoya complements a leading portfolio of ultra-sensitive biomarker detection technologies, together enabling a more complete view of biology and disease across both tissue and blood. Our Commitment to Employees: At Quanterix, our values are based on: Team, Innovation, Customer and Owner. Team: Challenge assumptions, not the person. Respect diversity of thought and hold ourselves to lofty standards Innovation: Stay curious, experiment, create and change Customer: Prioritize and celebrate these pioneers by doing our best to deliver on commitments Owner: Act with high integrity and in the best interest of Quanterix. Take measured risks and learn from their success and failures. We reward and recognize our employees by offering competitive compensation and a 401k plan with employer match, as well as competitive health, dental, and vision benefits for employees and their dependents. We also offer an unlimited vacation policy to all exempt employees, and a generous PTO policy for non-exempt employees. All employees are eligible for equity, employee stock purchase plan, a performance bonus, and 1:1 financial counseling/planning. We also offer Tuition Assistance. We have a free, state-of-the-art onsite fitness center for all employees. To keep you fueled up, we provide onsite employees free snacks and drinks every day! DIVERSE & INCLUSIVE WORKPLACE: Quanterix is committed to a Diverse and Inclusive workplace. We strive to recruit candidates who will bring inclusive mindsets and contribute to our values. Quanterix is an Equal Opportunity Employer and does not discriminate based on race, national origin, gender, gender identity, sexual orientation, protected veteran status, disability, age, or other legally protected status. Quanterix will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.