Associate Scientist

Position Title: Associate Scientist

Work Location: Boston, MA 02115

Assignment Duration: 12 months

Position Summary:

• This is an exciting opportunity in the Biochemistry and Biophysics Group within the Department of Pharmacology at our organization.

Key Responsibilities:

• Develop and/or run quantitative biochemical and biophysical assays to support identification, characterization, and optimization of small molecule ligands from high throughput screening campaigns and medicinal chemistry efforts.
• Conduct biochemical and biophysical studies to elucidate the modes of ligand interaction and mechanisms of action on target proteins.

Qualification & Experience:

• BS/BA degree in biochemistry, biophysics or a related discipline with a minimum of 1-5 years industry experience; or a MS degree in biochemistry, biophysics or a related discipline with 1 or more years of industry experience, preferably with a focus on assay development and compound profiling within a drug discovery environment.
• Candidate should have basic knowledge of biochemistry, biophysics and molecular biology.
• Candidate should have prior experience with basic biochemical and/or biophysical techniques.
• Candidate should be highly motivated, driven, and willing to take the initiative to learn new scientific methodologies.
• Candidate should be a strong team player.
• Candidate should have excellent oral and written communication skills.
• Candidate should be comfortable using a PC computer and proficient in Windows-based operating systems and basic applications, such as spreadsheets and databases.
• Experience in the use of automated liquid handlers such as Echo, Bravo, Biomek, or Hamilton and data analysis and presentation software such as TIBCO Spotfire, Excel and PowerPoint.
• Proven ability to independently design, develop and implement biochemical and biophysical screening assays using detection modalities such as: TR-FRET, FP, LC-MS, radiochemical, surface plasmon resonance (BIAcore), fluorescence-based thermal shift (TdF), and/or isothermal titration calorimetry (ITC).
• Hands-on experience performing steady-state and transient-state kinetic experiments to study enzymes and inhibitors.
• Direct experience in recombinant protein expression using bacteria, insect (baculovirus) and/or mammalian cell-based systems and purification using automated chromatographic separation systems.