Postdoctoral Fellow \ Neuroscience

Society for Neuroscience
United States, Pennsylvania, Philadelphia
Jun 05, 2025
Postdoctoral Fellow \ Neuroscience Employer The Children's Hospital of Philadelphia/University of Pennsylvania Location Philadelphia, Pennsylvania Salary $66,300 for Year 0; payscale here: https://careers.chop.edu/us/en/postdoctoral-fellows Closing date Aug 3, 2025 View more categories View less categories Sector Graduate School or University, Hospital, Independent Research Institute Job Function Postdoctoral Researcher Research Area Development, Neural Excitability, Synapses, & Glia, Neurodegenerative Disorders & Injury, Techniques Position Type Full Time Level Any Experience Level Considered Description The laboratory of Ethan Goldberg has an open postdoctoral fellowship position in neuroscience. The lab studies basic mechanisms of neurodevelopmental disorders in a range of model systems including ion channel physiology, neurons and neuronal organoids derived from human induced pluripotent stem cells, acute brain slice physiology, and calcium and voltage imaging in vitro and in awake, behaving experimental animals in vivo. Ongoing projects in the lab include: basic mechanisms of febrile seizures and the effect of environmental temperature on brain function; basic and translational mechanisms of Dravet syndrome and other neurodevelopmental disorders due to ion channelopathy; basic mechanisms of action potential generation and propagation and synaptic transmission. Desired Skills and Experience Ph.D. in Neuroscience or applied field (electrical or biomedical engineering, computer science). Prior experience with electrophysiology, imaging, cell culture, transcriptomics, and/or computational neuroscience, is preferred. Recent Publications -- Rosenthal ZP, Majeski JB, Somarowthu A, [...] Yodh AG, Goldberg EM. 2025. Electroconvulsive therapy generates a postictal wave of spreading depolarization in mice and humans. Nat Commun; 16(1):4619. PMID: 40383825 -- Clatot J, Currin CB, Liang Q, Pipatpolkai T, Massey SL, Helbig I, Delemotte L, Vogels TP, Covarrubias M, Goldberg EM. 2024. A structurally precise mechanism links an epilepsy-associated KCNC2 potassium channel mutation to interneuron dysfunction. Proc Natl Acad Sci U S A; 121(3):e2307776121. PMID: 38194456 -- Qu G, Merchant JP, Clatot J, [...] Anderson SA, Goldberg EM. 2024. Targeted blockade of aberrant sodium current in a stem cell-derived neuron model of SCN3A encephalopathy. Brain. 2024 Apr 4;147(4):1247-1263. PMID: 37935051 -- Goff KM, Liebergall SR, Jiang E, Somarowthu A, Goldberg EM. 2023. VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome. Cell Rep; 42(6):112628. PMID: 37310860 -- Kaneko K, Currin CB, Goff KM, Wengert ER, Somarowthu A, Vogels TP, Goldberg EM. 2022. Developmentally regulated impairment of parvalbumin interneuron synaptic transmission in an experimental model of Dravet syndrome. Cell Rep; 38(13):110580. PMID: 35354025 About the Employer Dr. Goldberg is Associate Professor in the Departments of Neurology and Neuroscience at the University of Pennsylvania and Division of Neurology at the Children's Hospital of Philadelphia. The Children's Hospital of Philadelphia is an elite children's hospital with a long and distinguished tradition of research that has spanned nearly a century. The research breakthroughs at Children's Hospital have improved the lives of countless children. The Hospital's research enterprise is organized under the CHOP Research Institute, which is part of the larger University of Pennsylvania neuroscience community with over 200 neuroscience faculty.