Staff Associate I

Job Summary

The Staff Associate I will work with a team of researchers for the Taub Institute for Research on Alzheimer's Disease and the Aging Brain. The nature of the research is understanding cellular and molecular mechanisms of Alzheimer's disease, cognitive aging, and related disorders. S/he will also contribute conceptual as well as interpretive assistance to the development and implementation of novel ideas that involve possible therapeutic approaches to drug discovery for Alzheimer's disease. Perform other related duties as assigned.

Responsibilities

Conducting various wet lab experiments including but not limited to iPSC derived neuronal and glial cultures. Tissue processing, Western blotting, PCR and DNA gel electrophoresis, ELISA, RNA FISH, and Fluorescent immunohistochemistry.

Maintaining animal colonies (primarily mice), genotyping and setting up breeding to generate mice of high quality, including care and feeding, cleaning of the equipment and physical surroundings, and monitoring the health of each animal.

Learn new protocols and experimental techniques to conduct and implement novel experiments in the lab.

Candidate is expected to pay close attention to even minor details while conducting experiments.

Bachelor's degree in specific research field and 4 years experience preferred.

Required Qualifications

Experienced in working with iPSC derived neuronal and glial cultures is a must. Candidate must have an understanding of the anatomy of mouse brain as well as experience working and maintaining a fully functional wet lab, including proficiency in the biochemistry techniques of Western Blotting, PCR and gel electrophoresis, ELISA, and immunohistochemistry, including relevant analytical techniques.

• Experience in Alzheimer's disease research.
• Experience with mouse husbandry in addition to perfusion, dissecting and slicing sections of the mouse brain using a cryostat.
• Proficient in cell culture techniques for primary cell lines and immortalized cells. Experience working with BSL2 biosafety cabinet.
• Proficient in data recording/analysis in statistical/spreadsheet formats (MS Excel, MS Word, Powerpoint, Prism).

Preferred Qualifications

• Master's degree in biomedical sciences and at least 6 years for lab experience.
• Experience and prior knowledge of molecular biology techniques is a plus but not required.
• Experience in stereotactic injection to the mouse brain.
• Experience in focused ultrasound of the mouse brain.
• Experience of working with glial cells (microglia & astrocytes) in mouse brain.

Columbia University is an Equal Opportunity Employer / Disability / Veteran

Pay Transparency Disclosure

The salary of the finalist selected for this role will be set based on a variety of factors, including but not limited to departmental budgets, qualifications, experience, education, licenses, specialty, and training. The above hiring range represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting.