Postdoctoral Fellow - Computational Multiomics

Join the forefront of groundbreaking research at City of Hope where we're changing lives and making a real difference in the fight against cancer, diabetes, and other life-threatening illnesses. Our dedicated and compassionate faculty and staff are driven by a common mission: Contribute to innovative approaches in predicting, preventing, and curing diseases, shaping the future of medicine through cutting-edge research.

One full-time postdoc position is available at Dr. June Wha-Rhee and Dr. Yun Rose Li's laboratory at Beckman Research Institute, City of Hope. The candidate will be jointly supervised by the two faculty members who are both physician scientists with shared research projects.

Dr. Rhee is a physician-scientist in the Division of Cardiology whose research focuses on understanding the biological mechanisms linking cardiovascular diseases with cancer and cancer therapies. She uses human-induced pluripotent stem cells (iPSCs), patient-derived samples, genomics, and computational biology to identify biomarkers and therapeutic targets aimed at improving cardiovascular outcomes for cancer patients.

Dr. Li is a physician scientist in radiation oncology whose research integrates genetic epidemiology, innovative sequencing and bioinformatics technologies including single cell and spatial transcriptomics, molecular biology approaches using cell-based and animal models, and biomarker studies from patients enrolled in clinical trials to better understand the role of metabolic dysfunction in cancer risk and treatment response.

As a successful candidate, you will:

Candidates are expected to demonstrate strong ability in the following areas:

• Technical skills in or very strong desire to become proficient in computational biology or bioinformatics, particularly with either metabolomics, proteomics and/or NGS including single cell and spatial profiling approaches (Strongly Preferred).
• Knowledge of wet lab aspects of metabolomics/proteomics including mass spectrometry or High-Performance Liquid Chromatography (HPLC), NGS or preparation of sequencing libraries for genomics, transcriptomic and single cell sequencing (Desired).
• Scientistic independence and critical thinking.
• Communication skills both orally and in writing.
• Data and project documentation and management.
• Willingness to teach and mentor junior trainees (Required).
• Be involved in grant proposal and manuscript writing and expected to pursue an independent scientific career after the postdoc training.
• During the training, the candidate will partner with our team members and external collaborators in serving as the scientific/technical expert to help drive our multiomics, high-throughput sequencing projects and help develop any projects based on the most advanced technologies.

Your qualifications should include:

• Ph.D. in Biochemistry, Bioinformatics, Genomics, or a related field such as Computer Science, Biomedical Sciences, Molecular and Cellular Biology, or Cell Biology, with demonstrated computational expertise. Individuals with background in physical sciences/computer science/engineering without biology backgrounds but who want to pivot to a future career in biomedical sciences are strongly encouraged to apply.
• The candidate must have at least 2 years of experience with coding in R, Matlab and/or Python, and already adapt to using the UNIX command line and executing analyses using high performance computing cluster.

Preferred qualifications:

• Prior experience in analyzing metabolomics and/or proteomics data.
• Prior wet lab experience with mass spectrometry, analytical chemistry, high-throughput sequencing library preparation, sequencing project planning and troubleshooting.

Additional Information:

• As the ideal candidate will be working primarily in either metabolomics/proteomics and/or genomics/computational biology, this is a position that is specified to be in-person for the first 12 months but can be eligible to be converted to a partially or largely remote role depending on performance, experience and fit.
• Please include your curriculum vitae and a cover letter with your application. The cover letter should contain a detailed personal statement outlining your previous research experience and explaining your interest in this position.

City of Hope employees pay is based on the following criteria: work experience, qualifications, and work location.

City of Hope is an equal opportunity employer. To learn more about our commitment to diversity, equity, and inclusion, please click here.

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