Research Associate I

POSITION SUMMARY:

The Schafer lab focuses on understanding how the immune system interacts with the nervous system to regulate brain plasticity and inflammation in disease (Alzheimer's, MS, autism, etc.). We use a variety of techniques such as confocal microscopy, single cell RNAseq, spatial transcriptomics, mouse genetics, and behavior to address how microglia modify synapses and, in turn, how these mechanisms go awry in disease. Our primary disease interests include, but are not limited to, autism, multiple sclerosis, and Alzheimer's disease. You can find more information at https://www.schaferlabumms.com/

Under the direction of the Principal Investigator (PI) or designee, the Research Associate I provides operational support to the laboratory. The Research Associate I will perform research experiments as defined by the PI.

ESSENTIAL FUNCTIONS:

Perform laboratory experiments and may be responsible for a single research project
• Utilize all software relevant to experiment and equipment used
• Interpret data, form conclusions and decide on next steps under the direction of the PI or designee
• Maintain accurate records, may modify protocols with the approval of the PI or designee
• Review literature, publications and grants relevant to assigned projects
• Record results according to established lab, sponsor & university protocol
• Assist with performing data analysis and/or mathematical computations
• Maintain a detailed lab notebook according to lab practice
• Present findings at lab/group meetings
• Monitor laboratory supply levels and order as noted
• Prepare and label buffers, media, solutions, etc.
• Assist with and comply with all safety regulation and infection control standards
• Train on IACUC, IRB, EHS, Radiation safety protocols
• Comply with all applicable state, federal university, and sponsor policies and agreements
• Provide support with identifying problems and challenges, propose resolutions, implement appropriate solutions
• Provide support with drafting standard operation procedures in compliance to EHS regulation specific for the lab
• Perform other duties as required

REQUIRED QUALIFICATIONS:

• Bachelor's degree in Biological or Natural Science, or equivalent experience
• Basic understanding of lab safety and protocols
• Knowledge of Microsoft Office products
• Ability to analyze data in a quantitative and objective manner.
• Ability to work in a team environment

The RA Grade 40 positions will provide technical support on collaborative projects to assess how the immune system and immune cells impact the brain in the context of aging and neurodegeneration. There will also be opportunities to take on independent projects. Among the techniques that a RA would be involved in include preparation of brain tissue for immunofluorescence microscopy, confocal and super resolution imaging, tissue culture, preparation of tissue for RNA sequencing, and spatial transcriptomics. Candidates should feel comfortable working with mice, work well in a group, and have a strong ability to multi-task. Skills that are preferred but are not required include preparation of tissue for immunofluorescence microscopy, experience imaging on a microscope, experience in coding, and experience with tissue dissection.

Interested individuals should reach out to Dr. Dori Schafer at Dorothy.schafer@umassmed.edu.