Scientist/Sr. Scientist DMPK

Scientist / Senior Scientist DMPK

COMPANY OVERVIEW:

Inotiv's Discovery & Translational Sciences Division (DTS) is an interdisciplinary drug discovery and innovation extension of its Drug Safety Assessment CRO business. Committed to scientific investigation at the early stages of discovery and preclinical development, DTS serves the interests of traditional pharmaceutical and biopharmaceutical companies and participates in the discovery of small molecule therapies and novel biotherapeutic modalities. With an emphasis placed on tailored solutions for each study, project, or program, Inotiv's DTS scientific team works with its clients to scope discovery staged pharmacology, toxicology, pathology, drug metabolism, and pharmacokinetic investigations. Assembling the right pharmacology model, scientific tools or analytical framework, as well as designing and platforming new technology, we commit ourselves to deliver for the client. Most importantly, we bring a team of scientific leaders to each project. The contributions of our teams originate from multiple locations spanning several discovery sites, including Boulder (Colorado), St Louis (Missouri), Nashville (Tennessee) and Research Triangle Park (North Carolina).

Inotiv's most valuable asset is our people.

POSITION SUMMARY:

Inotiv's accelerating growth is fueled in part by a drive to contemporize and innovate across the organization. As Inotiv leverages internal collaboration and diversification to offer best-in-class service to customers, we are committed to continuously developing Biotransformation science and solutions for clients covering the discovery through development continuum without a compromise to quality.

As demand for Inotiv's Biotransformation services increase, the need for innovative laboratory science and solutions, including the strategic incorporation of automation, will become increasingly important as we evolve and to adapt to scale these critical needs to a dynamic and rapidly growing department. As such the Inotiv DMPK department is seeking a Scientist to play a key role in this evolution.

The Scientist should have excellent knowledge and experience in biotransformation and traditional enzymology assay development, with an interest in continued innovation in the in vitro DMPK arena. The individual will be responsible for design, execution, analysis, interpretation, and communication of studies conducted. Experience in metabolic reaction mechanism and structural elucidation of metabolites is beneficial. Technical prowess in automated liquid handling including programming and LC-MS/MS bioanalysis is desirable. As this position presents an opportunity to interface with clients, an understanding of the drug discovery process as well as early-stage pharmaceutical development is also desired.The candidate will have hands-on experience in independently performing in vitro ADME assays and mass spectrometry-based analytical techniques for small molecules and ideally also with biologics (peptides, oligonucleotides, macrocycles, etc.). The candidate will spend a majority of their time in the lab conducting experiments and leading from the bench.

The Scientist will work closely with DMPK leadership and scientific group leaders as consummate bridge-builders interface between DMPK scientists and project teams (inter-site and inter-departmental), to effectively manage expectations and client satisfaction. The Scientist will serve as the Principal Investigator for specific studies for which they are the subject matter expert. The Scientist will thrive in a collaborative and welcoming environment that values a culture of empowerment, transparency, innovation, agility, professional growth, and credibility.

ESSENTIAL DUTIES & RESPONSIBILITIES:

• in vitro enzymology assay development, experimental design, study conduct, and

bioanalytical support to evaluate ADME properties of drug candidates

• Independently perform in vitro ADME assays
• Platforming high throughput screening assays on a Tecan automated liquid handling system
• Perform analysis and interpretation of traditional drug metabolizing enzyme substrate and

inhibition in vitro studies

• Generating ADME results and reports within client timelines, ensuring any

deviations are reflected as appropriate, and that the analyses and reporting are accurate

• Have an advanced knowledge of the drug discovery process and how bioanalysis fits into the

process

• Participating in client teleconferences with Principal Investigators and Laboratory

Management when appropriate

• Providing leadership in the development of new procedures and processes in the laboratory
• Demonstrating an understanding of Best Practices, SOPs and Good Laboratory Practices
• Performing all other duties and responsibilities as defined in applicable SOPs

PROFESSIONAL QUALIFICATIONS:

Education/Experience:

• BS or equivalent degree in Chemistry, Biochemistry, or related field, and 5+ years qualified

experience or M.S./Ph.D. with 1-3 years of experience in in vitro ADME assays, bioanalytical

analyses or structure elucidation of metabolites

• The exceptional candidate will have experience in the use of automated liquid handling system, high throughput screening, in vitro assay development DMPK drug-discovery experience in a pharmaceutical or biotech environment, ideally with both large (biologics) and small molecules

Skills, Specialized Knowledge and Abilities:

• Have a basic understanding of biotransformation / drug metabolism and pharmacokinetics

and have experience conducting in vitro ADME assays

• Background and skills in LC-MS/MS method development and analysis for quantitation
• Knowledge of DMPK experimental aspects and bioanalytical techniques, including mass spectrometry, microsomal stability assays, metabolite identification, CYP inhibition and induction, covalent binding, plasma protein binding, and solubility determination
• A detailed and specific understanding of all the processes related to Bioanalysis including sample preparation, standard calibration, quality control, instrument operation and troubleshooting, advanced troubleshooting, advanced method development, data processing and reporting
• Experience, skills, and abilities must include knowledge of enzyme kinetics, routine bioanalytical techniques including wet chemistry separations, liquid chromatography, and mass spectrometric analysis, instrument operation, and data processing
• Displays versatility and accuracy performing laboratory operations, some of which may be difficult and/or non-routine
• Excellent people skills and an ability & willingness to work on a multidisciplinary R&D team
• Independent, creative, detail-oriented, and a critical thinker

• A working knowledge and awareness of general laboratory procedures.
• Good written and oral communication skills

PERSONAL QUALIFICATIONS:

• Self-driven, creative, and entrepreneurial by being resourceful, optimistic, fiscally

responsible, innovative, fearless, determined, open-minded, and focused

• Balanced and dynamic communication style that radiates honesty, integrity, and credibility through effective use of active listening skills and follow through
• Superior relationship-building skills with all levels of internal and external stakeholders and clients

• Compelled to join highly desirable and sought-after employer that will drive development

toward their aspirations

• Naturally inquisitive and adept at crafting lines of questions that reveal deep and complete insights into situations and challenges
• Self-assured and confident, yet humble and open-minded; place the team ahead of personal

interests and ambitions

• Solutions-oriented personality that embraces challenges as opportunities and demonstrates a persistent drive to take initiative and diplomatically resolve issues or challenges
• Strong sense of personal accountability and responsibility; propels throughout the organization
• Assertive and driven to exceed expectations in a way that inspires others to do the same.
• Exceptional attention to detail and quality; strong organizational capabilities

At Inotiv our team members come together in support of an organization focused on delivering the experience, knowledge, and responsiveness demanded from an industry striving to bring new cures to market more safely and faster than ever before. Come join our team!

Salary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, 401K participation with company match, etc.

Inotiv is an equal opportunity employer and an E-Verify employer.

*This position could be offered at different levels for candidates who qualify with a combination of advanced levels of education and/or years of experience. The salary range will adjust along with the level of the role to match the person's relevant experience and/or education level.

Inotiv is a growing contemporary drug discovery and development company where we "Play to Win" in an industry rich with opportunity. Together, we face challenges and together we win in the delivery of world-class drug discovery and development solutions that impact the health and well-being of people all over the world. There's an opportunity for everyone at all phases of a career, each individual's unique skill set has an impact on the work we conduct. If you have the talent and desire to impact the quality of people's lives, we have the career opportunities to make it happen. Join us in embracing research and science to impact the health and well-being of people all over the world.

Salary will be commensurate with experience and responsibilities. Benefits include health and dental coverage, short- and long-term disability, paid time off, paid parental leave, 401K, and more!

Inotiv is an Equal Opportunity Employer. It is our policy to provide a fair and equal employment opportunity to all persons, regardless of age, race, color, religion, sex, gender, gender identity, gender expression, sexual orientation, genetic information, disability, national origin, veteran status, or any other basis prohibited by law. This policy governs all aspects of employment, including selection, job assignment, compensation, discipline, termination and access to benefits and training.